Nelfinavir Suppresses Insulin Signaling and Nitric Oxide Production by Human Aortic Endothelial Cells: Protective Effects of Thiazolidinediones

BACKGROUND: In human immunodeficiency virus 1 (HIV-1)–infected individuals, exposure to a protease inhibitor (PI)-based highly active antiretroviral therapy (HAART) regimen increases cardiovascular disease and endothelial dysfunction. However, the mechanisms of PI-induced effects on endothelial cell...

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Main Authors: Mondal, Debasis, Liu, Kai, Hamblin, Milton, Lasky, Joseph A., Agrawal, Krishna C.
Format: Artigo
Jezik:Inglês
Izdano: the Academic Division of Ochsner Clinic Foundation 2013
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603192/
https://ncbi.nlm.nih.gov/pubmed/23533049
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