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Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epithelia

Multiple sodium and chloride channels on the apical surface of nasal epithelial cells contribute to periciliary fluid homeostasis, a function that is disrupted in patients with cystic fibrosis (CF). Among these channels is the chloride channel CLCN2, which has been studied as a potential alternative...

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Détails bibliographiques
Auteurs principaux: Schiffhauer, Eric S., Vij, Neeraj, Kovbasnjuk, Olga, Kang, Po Wei, Walker, Doug, Lee, Seakwoo, Zeitlin, Pamela L.
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602739/
https://ncbi.nlm.nih.gov/pubmed/23316067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00277.2012
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