Metallothionein-induced zinc partitioning exacerbates hyperoxic acute lung injury

Hypozincemia, with hepatic zinc accumulation at the expense of other organs, occurs in infection, inflammation, and aseptic lung injury. Mechanisms underlying zinc partitioning or its impact on extrahepatic organs are unclear. Here we show that the major zinc-binding protein, metallothionein (MT), i...

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Main Authors: Lee, Sang-Min, McLaughlin, Joseph N., Frederick, Daniel R., Zhu, Lin, Thambiayya, Kalidasan, Wasserloos, Karla J., Kaminski, Iris, Pearce, Linda L., Peterson, Jim, Li, Jin, Latoche, Joseph D., Peck Palmer, Octavia M., Stolz, Donna Beer, Fattman, Cheryl L., Alcorn, John F., Oury, Tim D., Angus, Derek C., Pitt, Bruce R., Kaynar, A. Murat
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2013
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602737/
https://ncbi.nlm.nih.gov/pubmed/23275622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00243.2012
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