Membrane Docking Geometry and Target Lipid Stoichiometry of Membrane-Bound PKCα C2 Domain: A Combined Molecular Dynamics and Experimental Study

Protein kinase Ca (PKCα) possesses a conserved C2 domain (PKCα C2) that acts as a Ca(2+)-regulated membrane targeting element. Upon activation by Ca(2+), PKCα C2 directs the kinase protein to the plasma membrane, thereby stimulating an array of cellular pathways. At sufficiently high Ca(2+) concentr...

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Hlavní autoři: Lai, Chun-Liang, Landgraf, Kyle E., Voth, Gregory A., Falke, Joseph J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602446/
https://ncbi.nlm.nih.gov/pubmed/20659476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.07.037
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