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Membrane Docking Geometry and Target Lipid Stoichiometry of Membrane-Bound PKCα C2 Domain: A Combined Molecular Dynamics and Experimental Study
Protein kinase Ca (PKCα) possesses a conserved C2 domain (PKCα C2) that acts as a Ca(2+)-regulated membrane targeting element. Upon activation by Ca(2+), PKCα C2 directs the kinase protein to the plasma membrane, thereby stimulating an array of cellular pathways. At sufficiently high Ca(2+) concentr...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3602446/ https://ncbi.nlm.nih.gov/pubmed/20659476 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.07.037 |
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