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Molecular Mechanism of Membrane Binding of the GRP1 PH Domain
The pleckstrin homology (PH) domain of the general receptor of phosphoinositides 1 (GRP1) protein selectively binds to a rare signaling phospholipid, phosphatidylinositol (3,4,5)-trisphosphate (PIP(3)), in the membrane. The specific PIP(3) lipid docking of GRP1 PH domain is essential to protein cell...
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| Publié dans: | J Mol Biol |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4265004/ https://ncbi.nlm.nih.gov/pubmed/23747485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.05.026 |
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