Ablation of the Microglial Protein DOCK2 Reduces Amyloid Burden in a Mouse Model of Alzheimer’s Disease

Alzheimer’s disease (AD) neuropathology is characterized by innate immune activation primarily through prostaglandin E2 (PGE(2)) signaling. Dedicator of cytokinesis 2 (DOCK2) is a guanyl nucleotide exchange factor expressed exclusively in microglia in the brain and is regulated by PGE(2) receptor EP...

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Autori principali: Cimino, Patrick J., Yang, Yue, Li, Xianwu, Hemingway, Jake F., Cherne, Makenzie K., Khademi, Shawn B., Fukui, Yoshinori, Montine, Kathleen S., Montine, Thomas J., Keene, C. Dirk
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602334/
https://ncbi.nlm.nih.gov/pubmed/23318649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexmp.2013.01.002
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