Prostaglandin E(2) Receptor Subtype 2 Regulation of Scavenger Receptor CD36 Modulates Microglial Aβ(42) Phagocytosis

Recent studies underline the potential relevance of microglial innate immune activation in Alzheimer disease. Primary mouse microglia that lack prostaglandin E2 receptor subtype 2 (EP2) show decreased innate immune-mediated neurotoxicity and increased amyloid β (Aβ) peptide phagocytosis, features th...

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Vydáno v:Am J Pathol
Hlavní autoři: Li, Xianwu, Melief, Erica, Postupna, Nadia, Montine, Kathleen S., Keene, C. Dirk, Montine, Thomas J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2015
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4278245/
https://ncbi.nlm.nih.gov/pubmed/25452117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2014.09.016
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