A novel KIT-deficient mouse mast cell model for the examination of human KIT-mediated activation responses

Activation of KIT, by its ligand, stem cell factor (SCF), results in the initiation of signal transduction pathways that influence mast cell survival and proliferation. Activating mutations in KIT have thus been linked to clonal MC proliferation associated with systemic mastocytosis. SCF also modula...

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Hauptverfasser: Smrž, Daniel, Bandara, Geethani, Zhang, Shuling, Mock, Beverly A., Beaven, Michael A., Metcalfe, Dean D., Gilfillan, Alasdair M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602326/
https://ncbi.nlm.nih.gov/pubmed/23357051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jim.2013.01.008
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