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The Bcl6 Target Gene MicroRNA-21 Promotes Th2 Differentiation by a T Cell Intrinsic Pathway
The transcriptional repressor Bcl6 is a critical regulator of T helper cell fate, and inhibits Th2-type inflammation. We have found that microRNA-21 (miR-21) is a novel target gene for Bcl6 in Treg cells. Bcl6 represses miR-21 transcription through a Stat3 binding element in the promoter, indicating...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3602238/ https://ncbi.nlm.nih.gov/pubmed/23416424 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2013.01.006 |
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