Preclinical and Clinical Studies of Gamma Secretase Inhibitors with Docetaxel on Human Breast Tumors

PURPOSE: Accumulating evidence supports the existence of breast cancer stem cells (BCSCs), which are characterized by their capacity to self-renew and divide indefinitely, and resistance to conventional therapies. The Notch pathway is important for stem cell renewal, and is a potential target for BC...

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Detalhes bibliográficos
Main Authors: Schott, Anne F., Landis, Melissa D., Dontu, Gabriela, Griffith, Kent A., Layman, Rachel M., Krop, Ian, Paskett, Lacey A, Wong, Helen, Dobrolecki, Lacey E., Froehlich, Amber M., Paranilam, Jaya, Hayes, Daniel F., Wicha, Max S., Chang, Jenny C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602220/
https://ncbi.nlm.nih.gov/pubmed/23340294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-3326
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