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DNA damage activates a complex transcriptional response in murine lymphocytes that includes both physiological and cancer-predisposition programs

BACKGROUND: Double strand (ds) DNA breaks are a form of DNA damage that can be generated from both genotoxic exposures and physiologic processes, can disrupt cellular functions and can be lethal if not repaired properly. Physiologic dsDNA breaks are generated in a variety of normal cellular function...

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Autors principals: Innes, Cynthia L, Hesse, Jill E, Palii, Stela S, Helmink, Beth A, Holub, Abigail J, Sleckman, Barry P, Paules, Richard S
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602184/
https://ncbi.nlm.nih.gov/pubmed/23496831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-14-163
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