Dissecting cellular responses to irradiation via targeted disruptions of the ATM-CHK1-PP2A circuit

Exposure of proliferating cells to genotoxic stresses activates a cascade of signaling events termed the DNA damage response (DDR). The DDR preserves genetic stability by detecting DNA lesions, activating cell cycle checkpoints and promoting DNA damage repair. The phosphoinositide 3-kinase-related k...

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Bibliographic Details
Main Authors: Palii, Stela S., Cui, Yuxia, Innes, Cynthia L., Paules, Richard S.
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3646866/
https://ncbi.nlm.nih.gov/pubmed/23462183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.24127
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