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Interferons and interleukin-6 suppress the DNA-binding activity of E2F in growth-sensitive hematopoietic cells.

Transcription factor E2F binds to cellular promoters of certain growth- and cell cycle-controlling genes and forms distinct heteromeric complexes with other nuclear proteins. We show here that alpha and beta interferons (alpha, beta) and interleukin-6 abolished the E2F-containing DNA-binding complex...

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Bibliografische gegevens
Hoofdauteurs: Melamed, D, Tiefenbrun, N, Yarden, A, Kimchi, A
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1993
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC360214/
https://ncbi.nlm.nih.gov/pubmed/7689148
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