The Role of miR-18b in MDM2-p53 Pathway Signaling and Melanoma Progression

BACKGROUND: Although p53 is inactivated by point mutations in many tumors, melanomas infrequently harbor mutations in the p53 gene. Here we investigate the biological role of microRNA-18b (miR-18b) in melanoma by targeting the MDM2-p53 pathway. METHODS: Expression of miR-18b was examined in nevi (n...

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Hauptverfasser: Dar, Altaf A, Majid, Shahana, Rittsteuer, Claudia, de Semir, David, Bezrookove, Vladimir, Tong, Schuyler, Nosrati, Mehdi, Sagebiel, Richard, Miller, James R., Kashani-Sabet, Mohammed
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601951/
https://ncbi.nlm.nih.gov/pubmed/23365201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djt003
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