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The Role of miR-18b in MDM2-p53 Pathway Signaling and Melanoma Progression
BACKGROUND: Although p53 is inactivated by point mutations in many tumors, melanomas infrequently harbor mutations in the p53 gene. Here we investigate the biological role of microRNA-18b (miR-18b) in melanoma by targeting the MDM2-p53 pathway. METHODS: Expression of miR-18b was examined in nevi (n...
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| Auteurs principaux: | , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3601951/ https://ncbi.nlm.nih.gov/pubmed/23365201 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djt003 |
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