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Detecting Rare Variant Effects Using Extreme Phenotype Sampling in Sequencing Association Studies
In the increasing number of sequencing studies aimed at identifying rare variants associated with complex traits, the power of the test can be improved by guided sampling procedures. We confirm both analytically and numerically that sampling individuals with extreme phenotypes can enrich the presenc...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3601902/ https://ncbi.nlm.nih.gov/pubmed/23184518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.21699 |
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