Smad3 Controls β-1,3-Glucuronosyltransferase 1 Expression in Rat Nucleus Pulposus Cells: Implications of Dysregulated Expression in Disc Disease

OBJECTIVE: To study the regulation of expression of β-1,3-glucuronosyltransferase 1 (GlcAT-1), an important regulator of glycosaminoglycan (GAG) synthesis, by Smad3 in nucleus pulposus (NP) cells. METHODS: GlcAT-1 expression was examined in rat NP and anulus fibrosus (AF) cells treated with transfor...

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Main Authors: Wu, Qianghua, Wang, Jianru, Skubutyte, Renata, Kepler, Christopher K., Huang, Zonggui, Anderson, D. Greg, Shapiro, Irving M., Risbud, Makarand V.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601452/
https://ncbi.nlm.nih.gov/pubmed/22674034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.34570
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