Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A.

Cyclic AMP (cAMP) regulates a number of eukaryotic genes by mediating the protein kinase A (PKA)-dependent phosphorylation of the CREB transcription factor at Ser-133. In this study, we test the hypothesis that the stoichiometry and kinetics of CREB phosphorylation are determined by the liberation a...

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Detalhes bibliográficos
Principais autores: Hagiwara, M, Brindle, P, Harootunian, A, Armstrong, R, Rivier, J, Vale, W, Tsien, R, Montminy, M R
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC360117/
https://ncbi.nlm.nih.gov/pubmed/8336722
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