Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A.

Cyclic AMP (cAMP) regulates a number of eukaryotic genes by mediating the protein kinase A (PKA)-dependent phosphorylation of the CREB transcription factor at Ser-133. In this study, we test the hypothesis that the stoichiometry and kinetics of CREB phosphorylation are determined by the liberation a...

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Bibliografiske detaljer

Udgivet i:	Mol Cell Biol
Principais autores:	Hagiwara, M, Brindle, P, Harootunian, A, Armstrong, R, Rivier, J, Vale, W, Tsien, R, Montminy, M R
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis 1993
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360117/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8336722/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.8.4852-4859.1993
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