Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A.

Cyclic AMP (cAMP) regulates a number of eukaryotic genes by mediating the protein kinase A (PKA)-dependent phosphorylation of the CREB transcription factor at Ser-133. In this study, we test the hypothesis that the stoichiometry and kinetics of CREB phosphorylation are determined by the liberation a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell Biol
Prif Awduron: Hagiwara, M, Brindle, P, Harootunian, A, Armstrong, R, Rivier, J, Vale, W, Tsien, R, Montminy, M R
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 1993
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360117/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8336722/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.8.4852
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