Both the basic region and the 'leucine zipper' domain of the cyclic AMP response element binding (CREB) protein are essential for transcriptional activation.

Second messengers like cAMP can activate the transcription of genes containing consesus cAMP response element (CRE). A 43 kd nuclear phosphoprotein previously identified as the cAMP response element binding (CREB) protein has been shown to bind as a dimer to CRE and activate gene transcription. The...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Dwarki, V J, Montminy, M, Verma, I M
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 1990
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC551651/
https://ncbi.nlm.nih.gov/pubmed/2136830
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