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Forging a link between oncogenic signaling and immunosuppression in melanoma
Immunosuppressive tumor microenvironments limit the efficacy of T cell-based immunotherapy. We have recently demonstrated that the inhibition of BRAF(V600E) with vemurafenib relieves interleukin-1 (IL-1)-induced T-cell suppression as mediated by melanoma tumor associated fibroblasts (TAFs). These re...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Landes Bioscience
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3601157/ https://ncbi.nlm.nih.gov/pubmed/23525189 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.22745 |
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