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Forging a link between oncogenic signaling and immunosuppression in melanoma

Immunosuppressive tumor microenvironments limit the efficacy of T cell-based immunotherapy. We have recently demonstrated that the inhibition of BRAF(V600E) with vemurafenib relieves interleukin-1 (IL-1)-induced T-cell suppression as mediated by melanoma tumor associated fibroblasts (TAFs). These re...

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Bibliographische Detailangaben
Hauptverfasser: Khalili, Jahan S., Hwu, Patrick, Lizée, Gregory
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601157/
https://ncbi.nlm.nih.gov/pubmed/23525189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.22745
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