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Blood-brain barrier transport of amyloid beta peptides in efflux pump knock-out animals evaluated by in vivo optical imaging

BACKGROUND: Aβ transport (flux) across the blood-brain barrier (BBB) is thought to contribute to the pathogenesis of Alzheimer’s disease as well as to elimination of toxic amyloid from the brain by immunotherapy. Several BBB transporters have been implicated in Aβ exchange between brain parenchyma a...

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Detalhes bibliográficos
Main Authors: Zhang, Wandong, Xiong, Huaqi, Callaghan, Debbie, Liu, Hong, Jones, Aimee, Pei, Ke, Fatehi, Dorothy, Brunette, Eric, Stanimirovic, Danica
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601014/
https://ncbi.nlm.nih.gov/pubmed/23432917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2045-8118-10-13
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