ABCG2 Is Upregulated in Alzheimer's Brain with Cerebral Amyloid Angiopathy and May Act as a Gatekeeper at the Blood–Brain Barrier for Aβ(1–40) Peptides

Alzheimer's disease (AD) is characterized by accumulation and deposition of Aβ peptides in the brain. Aβ deposition in cerebrovessels occurs in many AD patients and results in cerebral amyloid angiopathy (AD/CAA). Since Aβ can be transported across blood–brain barrier (BBB), aberrant Aβ traffic...

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Detalhes bibliográficos
Main Authors: Xiong, Huaqi, Callaghan, Debbie, Jones, Aimee, Bai, Jianying, Rasquinha, Ingrid, Smith, Catherine, Pei, Ke, Walker, Douglas, Lue, Lih-Fen, Stanimirovic, Danica, Zhang, Wandong
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2009
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745912/
https://ncbi.nlm.nih.gov/pubmed/19403814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5103-08.2009
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