Cholesterol retention in Alzheimer’s brain is responsible for high β- and γ-secretase activities and Aβ production

Alzheimer’s disease (AD) is characterized by overproduction of Aβ derived from APP cleavage via β- and γ-secretase pathway. Recent evidence has linked altered cholesterol metabolism to AD pathogenesis. In this study, we show that AD brain had significant cholesterol retention and high β- and γ-secre...

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Detalhes bibliográficos
Main Authors: Xiong, Huaqi, Callaghan, Debbie, Jones, Aimee, Walker, Douglas G., Lue, Lih-Fen, Beach, Thomas G., Sue, Lucia I., Woulfe, John, Xu, Huaxi, Stanimirovic, Danica B., Zhang, Wandong
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2720683/
https://ncbi.nlm.nih.gov/pubmed/18086530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2007.10.005
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