S-Adenosylmethionine Regulates Apurinic/Apyrimidinic Endonuclease 1 Stability: Implication in Hepatocarcinogenesis

BACKGROUND & AIMS: Genomic instability participates in the pathogenesis of hepatocellular carcinoma (HCC). Apurinic/apyrimidinic endonuclease 1 (APEX1) participates in the base excision repair of premutagenic apurinic/apyrimidinic (AP) sites. Mice deficient in methionine adenosyltransferase 1a (...

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Main Authors: TOMASI, MARIA LAUDA, IGLESIAS–ARA, AINHOA, YANG, HEPING, RAMANI, KOMAL, FEO, FRANCESCO, PASCALE, MARIA ROSA, MARTÍNEZ–CHANTAR, M. LUZ, MATO, JOSÉ M., LU, SHELLY C.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600984/
https://ncbi.nlm.nih.gov/pubmed/18983843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2008.09.026
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