Inhibition of human betaine–homocysteine methyltransferase expression by S-adenosylmethionine and methylthioadenosine

BHMT (betaine–homocysteine methyltransferase) remethylates homocysteine to form methionine. SAM (S-adenosylmethionine) inhibits BHMT activity, but whether SAM modulates BHMT gene expression is unknown. Transcriptional regulation of the human BHMT is also unknown. The present study examined regulatio...

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Detalhes bibliográficos
Main Authors: Ou, Xiaopeng, Yang, Heping, Ramani, Komal, Ara, Ainhoa Iglesias, Chen, Hui, Mato, José M., Lu, Shelly C.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698693/
https://ncbi.nlm.nih.gov/pubmed/16953798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20061119
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