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S-Adenosylmethionine Inhibits Lipopolysaccharide-Induced Gene Expression via Modulation of Histone Methylation

We previously showed that S-adenosylmethionine (SAMe) and its metabolite methylthioadenosine (MTA) blocked lipopolysaccharide (LPS)-induced tumor necrosis factor α (TNFα) expression in RAW (murine macrophage cell line) and Kupffer cells at the transcriptional level without affecting nuclear factor κ...

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Bibliografske podrobnosti
Main Authors: Ara, Ainhoa Iglesias, Xia, Meng, Ramani, Komal, Mato, José M., Lu, Shelly C.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2408693/
https://ncbi.nlm.nih.gov/pubmed/18393372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.22231
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