Changes in the Expression of Methionine Adenosyltransferase Genes and S-adenosylmethionine Homeostasis during Hepatic Stellate Cell Activation

BACKGROUND AND RATIONALE: Hepatic stellate cell (HSC) activation is an essential event during liver fibrogenesis. Methionine adenosyltransferase (MAT) catalyzes biosynthesis of S-adenosylmethionine (SAMe), the principle methyl donor. SAMe metabolism generates two methylation inhibitors, methylthioad...

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Detalhes bibliográficos
Main Authors: Ramani, Komal, Yang, Heping, Kuhlenkamp, John, Tomasi, Lauda, Tsukamoto, Hidekazu, Mato, José M., Lu, Shelly C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905860/
https://ncbi.nlm.nih.gov/pubmed/20043323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.23411
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