IL-27 inhibits HIV-1 infection in human macrophages by down-regulating host factor SPTBN1 during monocyte to macrophage differentiation

The susceptibility of macrophages to HIV-1 infection is modulated during monocyte differentiation. IL-27 is an anti-HIV cytokine that also modulates monocyte activation. In this study, we present new evidence that IL-27 promotes monocyte differentiation into macrophages that are nonpermissive for HI...

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Bibliografische gegevens
Hoofdauteurs: Dai, Lue, Lidie, Kristy B., Chen, Qian, Adelsberger, Joseph W., Zheng, Xin, Huang, DaWei, Yang, Jun, Lempicki, Richard A., Rehman, Tauseef, Dewar, Robin L., Wang, Yanmei, Hornung, Ronald L., Canizales, Kelsey A., Lockett, Stephen J., Lane, H. Clifford, Imamichi, Tomozumi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600911/
https://ncbi.nlm.nih.gov/pubmed/23460728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20120572
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