IL-27 inhibits HIV-1 infection in human macrophages by down-regulating host factor SPTBN1 during monocyte to macrophage differentiation

The susceptibility of macrophages to HIV-1 infection is modulated during monocyte differentiation. IL-27 is an anti-HIV cytokine that also modulates monocyte activation. In this study, we present new evidence that IL-27 promotes monocyte differentiation into macrophages that are nonpermissive for HI...

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Main Authors: Dai, Lue, Lidie, Kristy B., Chen, Qian, Adelsberger, Joseph W., Zheng, Xin, Huang, DaWei, Yang, Jun, Lempicki, Richard A., Rehman, Tauseef, Dewar, Robin L., Wang, Yanmei, Hornung, Ronald L., Canizales, Kelsey A., Lockett, Stephen J., Lane, H. Clifford, Imamichi, Tomozumi
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600911/
https://ncbi.nlm.nih.gov/pubmed/23460728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20120572
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