Effect of Ritonavir on (99m)Technetium–Mebrofenin Disposition in Humans: A Semi-PBPK Modeling and In Vitro Approach to Predict Transporter-Mediated DDIs

A semiphysiologically based pharmacokinetic (semi-PBPK) model was developed to describe a unique blood, liver, and bile clinical data set for the hepatobiliary imaging agent (99m)Technetium–mebrofenin ((99m)Tc–mebrofenin), and to simulate sites/mechanisms of a (99m)Tc–mebrofenin–ritonavir drug–drug...

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Main Authors: Pfeifer, N D, Goss, S L, Swift, B, Ghibellini, G, Ivanovic, M, Heizer, W D, Gangarosa, L M, Brouwer, K L R
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2013
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600725/
https://ncbi.nlm.nih.gov/pubmed/23887590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2012.21
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