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Effect of Ritonavir on (99m)Technetium–Mebrofenin Disposition in Humans: A Semi-PBPK Modeling and In Vitro Approach to Predict Transporter-Mediated DDIs
A semiphysiologically based pharmacokinetic (semi-PBPK) model was developed to describe a unique blood, liver, and bile clinical data set for the hepatobiliary imaging agent (99m)Technetium–mebrofenin ((99m)Tc–mebrofenin), and to simulate sites/mechanisms of a (99m)Tc–mebrofenin–ritonavir drug–drug...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3600725/ https://ncbi.nlm.nih.gov/pubmed/23887590 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2012.21 |
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