Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility

Cigarette smoking is the major environmental risk factor for chronic obstructive pulmonary disease (COPD). Genome-wide association studies have provided compelling associations for three loci with COPD. In this study, we aimed to estimate direct, i.e., independent from smoking, and indirect effects...

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Detalhes bibliográficos
Main Authors: Siedlinski, Mateusz, Tingley, Dustin, Lipman, Peter J., Cho, Michael H., Litonjua, Augusto A., Sparrow, David, Bakke, Per, Gulsvik, Amund, Lomas, David A., Anderson, Wayne, Kong, Xiangyang, Rennard, Stephen I., Beaty, Terri H., Hokanson, John E., Crapo, James D., Lange, Christoph, Silverman, Edwin K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600068/
https://ncbi.nlm.nih.gov/pubmed/23299987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00439-012-1262-3
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