Analysis of 454 sequencing error rate, error sources, and artifact recombination for detection of Low-frequency drug resistance mutations in HIV-1 DNA

BACKGROUND: 454 sequencing technology is a promising approach for characterizing HIV-1 populations and for identifying low frequency mutations. The utility of 454 technology for determining allele frequencies and linkage associations in HIV infected individuals has not been extensively investigated....

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Main Authors: Shao, Wei, Boltz, Valerie F, Spindler, Jonathan E, Kearney, Mary F, Maldarelli, Frank, Mellors, John W, Stewart, Claudia, Volfovsky, Natalia, Levitsky, Alexander, Stephens, Robert M, Coffin, John M
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2013
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3599717/
https://ncbi.nlm.nih.gov/pubmed/23402264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-18
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