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Automated hierarchical classification of protein domain subfamilies based on functionally-divergent residue signatures

BACKGROUND: The NCBI Conserved Domain Database (CDD) consists of a collection of multiple sequence alignments of protein domains that are at various stages of being manually curated into evolutionary hierarchies based on conserved and divergent sequence and structural features. These domain models a...

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Detalhes bibliográficos
Main Authors: Neuwald, Andrew F, Lanczycki, Christopher J, Marchler-Bauer, Aron
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3599474/
https://ncbi.nlm.nih.gov/pubmed/22726767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-13-144
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