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Obtaining extremely large and accurate protein multiple sequence alignments from curated hierarchical alignments

For optimal performance, machine learning methods for protein sequence/structural analysis typically require as input a large multiple sequence alignment (MSA), which is often created using query-based iterative programs, such as PSI-BLAST or JackHMMER. However, because these programs align database...

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Detalhes bibliográficos
Publicado no:Database (Oxford)
Main Authors: Neuwald, Andrew F, Lanczycki, Christopher J, Hodges, Theresa K, Marchler-Bauer, Aron
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7297217/
https://ncbi.nlm.nih.gov/pubmed/32500917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/database/baaa042
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