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Nicotine Affects Bone Resorption and Suppresses the Expression of Cathepsin K, MMP-9 and Vacuolar-Type H(+)-ATPase d2 and Actin Organization in Osteoclasts

Tobacco smoking is an important risk factor for the development of several cancers, osteoporosis, and inflammatory diseases such as periodontitis. Nicotine is one of the major components of tobacco. In previous study, we showed that nicotine inhibits mineralized nodule formation by osteoblasts, and...

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Autors principals: Tanaka, Hideki, Tanabe, Natsuko, Kawato, Takayuki, Nakai, Kumiko, Kariya, Taro, Matsumoto, Sakurako, Zhao, Ning, Motohashi, Masafumi, Maeno, Masao
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3598738/
https://ncbi.nlm.nih.gov/pubmed/23555029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059402
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