Tension Force Downregulates Matrix Metalloproteinase Expression and Upregulates the Expression of Their Inhibitors through MAPK Signaling Pathways in MC3T3-E1 cells

Objective: Matrix metalloproteinases (MMPs), produced by osteoblasts, catalyze the turnover of extracellular matrix (ECM) molecules in osteoid, and the regulation of MMP activity depends on interactions between MMPs and tissue inhibitors of metalloproteinases (TIMPs). We focused on the degradation p...

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Pubblicato in:Int J Med Sci
Autori principali: Karasawa, Yoko, Tanaka, Hideki, Nakai, Kumiko, Tanabe, Natsuko, Kawato, Takayuki, Maeno, Masao, Shimizu, Noriyoshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ivyspring International Publisher 2015
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643081/
https://ncbi.nlm.nih.gov/pubmed/26640410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijms.13263
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