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Nicotine Affects Bone Resorption and Suppresses the Expression of Cathepsin K, MMP-9 and Vacuolar-Type H(+)-ATPase d2 and Actin Organization in Osteoclasts

Tobacco smoking is an important risk factor for the development of several cancers, osteoporosis, and inflammatory diseases such as periodontitis. Nicotine is one of the major components of tobacco. In previous study, we showed that nicotine inhibits mineralized nodule formation by osteoblasts, and...

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Main Authors: Tanaka, Hideki, Tanabe, Natsuko, Kawato, Takayuki, Nakai, Kumiko, Kariya, Taro, Matsumoto, Sakurako, Zhao, Ning, Motohashi, Masafumi, Maeno, Masao
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3598738/
https://ncbi.nlm.nih.gov/pubmed/23555029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059402
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