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Inhibition of Osteoclast Bone Resorption by Disrupting Vacuolar H(+)-ATPase a3-B2 Subunit Interaction

Vacuolar H(+)-ATPases (V-ATPases) are highly expressed in ruffled borders of bone-resorbing osteoclasts, where they play a crucial role in skeletal remodeling. To discover protein-protein interactions with the a subunit in mammalian V-ATPases, a GAL4 activation domain fusion library was constructed...

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書誌詳細
主要な著者: Kartner, Norbert, Yao, Yeqi, Li, Keying, Crasto, Gazelle J., Datti, Alessandro, Manolson, Morris F.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988353/
https://ncbi.nlm.nih.gov/pubmed/20837476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.123281
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