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Inhibition of Osteoclast Bone Resorption by Disrupting Vacuolar H(+)-ATPase a3-B2 Subunit Interaction
Vacuolar H(+)-ATPases (V-ATPases) are highly expressed in ruffled borders of bone-resorbing osteoclasts, where they play a crucial role in skeletal remodeling. To discover protein-protein interactions with the a subunit in mammalian V-ATPases, a GAL4 activation domain fusion library was constructed...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2988353/ https://ncbi.nlm.nih.gov/pubmed/20837476 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.123281 |
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