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A negative regulatory element in the bcl-2 5'-untranslated region inhibits expression from an upstream promoter.

bcl-2 mRNA is present at high levels in pre-B-cell lines but is down-regulated in most mature B-cell lines. To investigate the mechanisms responsible for its developmental control, we studied the regulation of bcl-2 expression in human B-lineage cell lines. Using nuclear run-on assays, we found that...

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Библиографические подробности
Опубликовано в: :Mol Cell Biol
Главные авторы: Young, R L, Korsmeyer, S J
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis 1993
Предметы:
Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359837/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8388542/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.6.3686
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