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A Transition-State Interaction Shifts Nucleobase Ionization Toward Neutrality to Facilitate Small Ribozyme Catalysis

One mechanism by which ribozymes can accelerate biological reactions is by adopting folds that favorably perturb nucleobase ionization. Herein we used Raman crystallography to directly measure pK(a) values for the Ade38 N1-imino group of a hairpin ribozyme in distinct conformational states. A transi...

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Autors principals: Liberman, Joseph A., Guo, Man, Jenkins, Jermaine L., Krucinska, Jolanta, Chen, Yuanyuan, Carey, Paul R., Wedekind, Joseph E.
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3598154/
https://ncbi.nlm.nih.gov/pubmed/22989273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3070528
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