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Structural effects of nucleobase variations at key active site residue Ade38 in the hairpin ribozyme
The hairpin ribozyme requires functional groups from Ade38 to achieve efficient bond cleavage or ligation. To identify molecular features that contribute to catalysis, structures of position 38 base variants 2,6-diaminopurine (DAP), 2-aminopurine (AP), cytosine (Cyt), and guanine (Gua) were determin...
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| Hoofdauteurs: | , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Cold Spring Harbor Laboratory Press
2008
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2491461/ https://ncbi.nlm.nih.gov/pubmed/18596253 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1055308 |
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