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A posteriori design of crystal contacts to improve the X-ray diffraction properties of a small RNA enzyme

The hairpin ribozyme is a small catalytic RNA comprising two helix–loop–helix domains linked by a four-way helical junction (4WJ). In its most basic form, each domain can be formed independently and reconstituted without a 4WJ to yield an active enzyme. The production of such minimal junctionless ha...

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Detalhes bibliográficos
Main Authors: MacElrevey, Celeste, Spitale, Robert C., Krucinska, Jolanta, Wedekind, Joseph E.
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483500/
https://ncbi.nlm.nih.gov/pubmed/17582172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S090744490702464X
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