Histone methyltransferase SETD2 coordinates FACT recruitment with nucleosome dynamics during transcription

Histone H3 of nucleosomes positioned on active genes is trimethylated at Lys36 (H3K36me3) by the SETD2 (also termed KMT3A/SET2 or HYPB) methyltransferase. Previous studies in yeast indicated that H3K36me3 prevents spurious intragenic transcription initiation through recruitment of a histone deacetyl...

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Hlavní autoři: Carvalho, Sílvia, Raposo, Ana Cláudia, Martins, Filipa Batalha, Grosso, Ana Rita, Sridhara, Sreerama Chaitanya, Rino, José, Carmo-Fonseca, Maria, de Almeida, Sérgio Fernandes
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
Gene Regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597667/
https://ncbi.nlm.nih.gov/pubmed/23325844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1472
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