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rDNA-directed integration by an HIV-1 integrase—I-PpoI fusion protein

Integrating viral vectors are efficient gene transfer tools, but their integration patterns have been associated with genotoxicity and oncogenicity. The recent development of highly specific designer nucleases has enabled target DNA modification and site-specific gene insertion at desired genomic lo...

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Bibliografiske detaljer
Main Authors: Schenkwein, Diana, Turkki, Vesa, Ahlroth, Mervi K., Timonen, Oskari, Airenne, Kari J., Ylä-Herttuala, Seppo
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597653/
https://ncbi.nlm.nih.gov/pubmed/23275537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1438
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