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Analysis of Hepatitis C Virus Decline during Treatment with the Protease Inhibitor Danoprevir Using a Multiscale Model

The current paradigm for studying hepatitis C virus (HCV) dynamics in patients utilizes a standard viral dynamic model that keeps track of uninfected (target) cells, infected cells, and virus. The model does not account for the dynamics of intracellular viral replication, which is the major target o...

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Bibliographic Details
Main Authors: Rong, Libin, Guedj, Jeremie, Dahari, Harel, Coffield, Daniel J., Levi, Micha, Smith, Patrick, Perelson, Alan S.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597560/
https://ncbi.nlm.nih.gov/pubmed/23516348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002959
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